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CALENDAR
Cochrane Database Syst Rev. 2011 Nov 9;(11):CD008456. doi: 10.1002/14651858.CD008456.pub2.
Source
Oral Health Unit, School
of Dentistry, The University
of Manchester, Manchester, UK. vishal.r.aggarwal@manchester.ac.uk.
ABSTRACT:
BACKGROUND:
Psychosocial factors have a role in the onset of chronic orofacial
pain. However, current management involves invasive therapies like occlusal
adjustments and splints which lack an evidence base.
OBJECTIVES:
To determine the efficacy of non-pharmacologic
psychosocial interventions for chronic orofacial pain.
SEARCH METHODS:
The following electronic databases were searched: the Cochrane
Oral Health Group Trials Register (to 25
October 2010), the Cochrane
Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010,
Issue 4), MEDLINE via OVID (1950 to 25 October 2010), EMBASE via OVID (1980 to
25 October 2010) and PsycINFO via OVID (1950 to 25 October 2010). There were no
restrictions regarding language or date of publication.
SELECTION CRITERIA:
Randomised controlled trials which included non-pharmacological
psychosocial interventions for adults with chronic orofacial pain compared with
any other form of treatment (e.g. usual care like intraoral splints,
pharmacological treatment and/or physiotherapy).
DATA COLLECTION AND ANALYSIS:
Data were independently extracted in duplicate. Trial authors were
contacted for details of randomisation and loss to follow-up, and
also to provide means and standard deviations for outcome measures where these
were not available. Risk of bias was assessed and disagreements between review authors
were discussed and another review author
involved where necessary.
MAIN RESULTS:
Seventeen trials were eligible for inclusion into the review.
Psychosocial interventions improved long-term
pain intensity (standardised mean difference (SMD) -0.34,
95% confidence interval (CI) -0.50 to -0.18) and depression (SMD -0.35,
95% CI -0.54 to -0.16). However, the risk of bias was high for almost all
studies. A subgroup analysis revealed that cognitive behavioural therapy (CBT)
either alone or in combination with biofeedback improved long-term
pain intensity, activity interference and depression. However the studies
pooled had high risk of bias and were few in number. The pooled trials were all
related to temporomandibular disorder (TMD).
AUTHORS' CONCLUSIONS:
There is weak evidence to support the use of psychosocial
interventions for chronic orofacial pain. Although significant effects were
observed for outcome measures where pooling was possible, the studies were few
in number and had high risk of bias. However, given the non-invasive
nature of such interventions they should be used in preference to other
invasive and irreversible treatments which also have limited or no efficacy.
Further high quality trials are needed to explore the effects of psychosocial
interventions on chronic orofacial pain.
Source
Oral Health and Health Research Programme, Dental Health Services
Research Unit, University
of Dundee, Scotland UK.
ABSTRACT:
DATA SOURCES:
Cochrane Oral Health Group's Trials Register, Central, Medline,
Embase, PsycINFO.
STUDY SELECTION:
Randomised controlled trials of psychosocial interventions for
chronic orofacial pain were included. Psychosocial interventions targeted
towards changing thoughts, behaviours and/or feelings that may exacerbate pain
symptoms through a vicious cycle were eligible. Primary outcomes were pain
intensity/severity, satisfaction with pain relief and quality of life.
DATA EXTRACTION AND SYNTHESIS:
Two reviewers independently screened studies, extracted data and
assessed risk of bias. Dichotomous outcomes, were expressed as risk ratios with
95% confidence intervals, continuous outcomes as mean differences with 95%
confidence intervals. Heterogeneity was assessed using the Cochrane test for
heterogeneity and the I2 test. Meta-analyses
were conducted using the random-effect or the fixed-effect
models.
RESULTS:
Fifteen of the 17 eligible studies were on temporomandibular
disorders (TMDs), two on burning mouth syndrome. Psychosocial interventions
improved long-term pain intensity (standardised mean difference (SMD) -0.34,
95% confidence interval (CI) -0.50 to -0.18) and depression (SMD -0.35,
95% CI -0.54 to -0.16). However, the risk of bias in these studies was high.
CONCLUSIONS:
There is weak evidence to support the use of psychosocial
interventions for chronic orofacial pain.
(Originally published in the Cochrane Database Syst Rev , EBD reprinted this article. They reviewed over 60 years of studies. Note the the risk of bias clause).